cosmosTNG is a constrained cosmological galaxy formation simulation suite in the COSMOS field at Cosmic Noon. CLAMATO Lyman-alpha forest flux and zCOSMOS galaxy positions are used to reconstruct the initial density field, which is subsequently evolved with the TNG galaxy formation model with the AREPO code. The simulation suite consists of 8 variations of the unconstrained small-scale modes evolved down to $z\approx 2.0$, containing the well-studied zFIRE protocluster region, which furthermore overlaps with JWST treasury programs COSMOS-Web and PRIMER.